EXPOSURE TO MATERIAL DIABETES ON THE OXIDATIVE STRESS, HYPOXIA, AND PANCREATIC CHANGES IN RAT PUPS DURING THE PERINATAL PERIOD

  • Dallaqua B São Paulo State University (Unesp), Laboratory of Experimental Research on Gynecology and Obstetrics - UNIPEX, Postgraduate Course on Tocogynecology, Botucatu/SP, Ph.D
  • Veronyca Gonçalves Paula Faculdade de Medicina de Botucatu - UNESP
  • Sinzato YK São Paulo State University (Unesp), Laboratory of Experimental Research on Gynecology and Obstetrics - UNIPEX, Postgraduate Course on Tocogynecology, Botucatu/SP, Ph.D
  • Gallego FQ São Paulo State University (Unesp), Laboratory of Experimental Research on Gynecology and Obstetrics - UNIPEX, Postgraduate Course on Tocogynecology, Botucatu/SP, Ph.D
  • Iessi IL São Paulo State University (Unesp), Laboratory of Experimental Research on Gynecology and Obstetrics - UNIPEX, Postgraduate Course on Tocogynecology, Botucatu/SP, Ph.D
  • Rodrigues T Federal University of ABC (UFABC), Center of Natural and Human Sciences (CCNH), Santo André, São Paulo State, Brazil Ph.D
  • Rinaldi JC São Paulo State University (UNESP), Laboratory of Extracellular Matrix Biology, Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Botucatu, São Paulo, Brazil, Ph.D
  • Dellela FK São Paulo State University (UNESP), Laboratory of Extracellular Matrix Biology, Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Botucatu, São Paulo, Brazil, Ph.D
  • Felisbino SL São Paulo State University (UNESP), Laboratory of Extracellular Matrix Biology, Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Botucatu, São Paulo, Brazil, Ph.D
  • Corrente JE São Paulo State University (UNESP), Research Support Office, Botucatu Medical School, Botucatu, Brazil, Ph.D
  • Volpato GT Federal University of Mato Grosso (UFMT), Laboratory of System Physiology and Reproductive Toxicology, Barra do Garças/MT, Ph.D
  • Damasceno DC São Paulo State University (Unesp), Laboratory of Experimental Research on Gynecology and Obstetrics - UNIPEX, Postgraduate Course on Tocogynecology, Botucatu/SP, Ph.D
Palavras-chave: Hyperglycemia, fetuses, redox status, hypoxia, rats

Resumo

We investigated the outcomes of intrauterine exposure to hyperglycemia on glycemic parameters, oxidative stress, hypoxia, and pancreatic islet in rats' fetuses and newborns. Diabetes was induced with streptozotocin in Postnatal day 1 – PND1, nondiabetic rats (control) received the buffer. The adult rats were mated, and their offspring were euthanized at birth and PND5 and 15 periods for blood, liver, and pancreas analysis. Maternal diabetes led to neonatal hyperglycemia, hyperinsulinemia, insulin resistance (higher HOMA-IR), and oxidative stress in PND5. On PND15, the antioxidant system was inefficient in blood and liver tissues. HIF-1α and PGC-1α of the pups did not show differences, confirming an inability to respond to hyperglycemic changes. Pancreatic islets showed a reduced area in PND5 and PND15. Maternal diabetes influences fetal plasticity and affects the area of the pancreatic islet, causing hyperglycemia, insulin resistance, and oxidative stress in fetuses and newborns.

Publicado
2025-01-28
Edição
v. 17 n. 1 (2025)
Seção
Ciências da Saúde

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