EXPOSURE TO MATERIAL DIABETES ON THE OXIDATIVE STRESS, HYPOXIA, AND PANCREATIC CHANGES IN RAT PUPS DURING THE PERINATAL PERIOD

  • Bruna Dallaqua São Paulo State University (Unesp), Laboratory of Experimental Research on Gynecology and Obstetrics - UNIPEX, Postgraduate Course on Tocogynecology, Botucatu/SP, Ph.D
  • Veronyca Gonçalves Paula Faculdade de Medicina de Botucatu - UNESP
  • Yuri Karen Sinzato São Paulo State University (Unesp), Laboratory of Experimental Research on Gynecology and Obstetrics - UNIPEX, Postgraduate Course on Tocogynecology, Botucatu/SP, Ph.D
  • Francianne Quintanilha Gallego São Paulo State University (Unesp), Laboratory of Experimental Research on Gynecology and Obstetrics - UNIPEX, Postgraduate Course on Tocogynecology, Botucatu/SP, Ph.D
  • Isabela Lovizutto Iessi São Paulo State University (Unesp), Laboratory of Experimental Research on Gynecology and Obstetrics - UNIPEX, Postgraduate Course on Tocogynecology, Botucatu/SP, Ph.D
  • Tiago Rodrigues Federal University of ABC (UFABC), Center of Natural and Human Sciences (CCNH), Santo André, São Paulo State, Brazil Ph.D
  • Jaqueline C Rinaldi São Paulo State University (UNESP), Laboratory of Extracellular Matrix Biology, Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Botucatu, São Paulo, Brazil, Ph.D
  • Flavia Karina Dellela São Paulo State University (UNESP), Laboratory of Extracellular Matrix Biology, Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Botucatu, São Paulo, Brazil, Ph.D
  • Sérgio Luis Felisbino São Paulo State University (UNESP), Laboratory of Extracellular Matrix Biology, Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Botucatu, São Paulo, Brazil, Ph.D
  • José Eduardo Corrente São Paulo State University (UNESP), Research Support Office, Botucatu Medical School, Botucatu, Brazil, Ph.D
  • Gustavo Tadeu Volpato Federal University of Mato Grosso (UFMT), Laboratory of System Physiology and Reproductive Toxicology, Barra do Garças/MT, Ph.D
  • Débora Cristina Damasceno São Paulo State University (Unesp), Laboratory of Experimental Research on Gynecology and Obstetrics - UNIPEX, Postgraduate Course on Tocogynecology, Botucatu/SP, Ph.D

Abstract

We investigated the outcomes of intrauterine exposure to hyperglycemia on glycemic parameters, oxidative stress, hypoxia, and pancreatic islet in rats' fetuses and newborns. Diabetes was induced with streptozotocin in Postnatal day 1 – PND1, nondiabetic rats (control) received the buffer. The adult rats were mated, and their offspring were euthanized at birth and PND5 and 15 periods for blood, liver, and pancreas analysis. Maternal diabetes led to neonatal hyperglycemia, hyperinsulinemia, insulin resistance (higher HOMA-IR), and oxidative stress in PND5. On PND15, the antioxidant system was inefficient in blood and liver tissues. HIF-1α and PGC-1α of the pups did not show differences, confirming an inability to respond to hyperglycemic changes. Pancreatic islets showed a reduced area in PND5 and PND15. Maternal diabetes influences fetal plasticity and affects the area of the pancreatic islet, causing hyperglycemia, insulin resistance, and oxidative stress in fetuses and newborns.

Published
2025-01-28
Issue
Vol. 17 No. 1 (2025)
Section
Ciências da Saúde

Os direitos de autoria dos artigos publicados neste periódico pertencem aos autores, com a revista detendo os direitos de primeira publicação. Devido à sua disponibilidade em uma revista de acesso público, os artigos estão disponíveis para uso gratuito em contextos educacionais, práticos e governamentais, com atribuições apropriadas. É essencial conceder o devido crédito aos autores e à fonte, incluir um link  e indicar se ocorreram modificações. Nestas circunstâncias, não é necessário obter permissão dos autores ou editores. Os autores têm a liberdade de estabelecer acordos adicionais independentes para a distribuição não exclusiva da versão publicada deste trabalho, como a publicação em um repositório institucional ou a inclusão em um capítulo de livro.